This paper, based on China's 29 cities' panel data, uses DEA model, at the constant scale benefits, to measure China's total factors energy efficiency under environmental constraints from 1995—2013. The result shows a declining trend from the east to the west and a rising regional gap. Foreign direct investment, GDP per capita and industrial structure have a positive influence on energy efficiency, but the capital per capita, coal consumption and governmental interference are negative. From the view of region, each factor is different in 〖JP3〗influence direction and intensity on energy efficiency in different regions. Capita per capita and coal consumption are negative and GDP per capita is positive. Industrial structure is outstanding positive in the eastern China, not outstanding in the central and western China. Foreign direct investment is not outstanding in the eastern China, outstanding positive in the central, negative in the western. Governmental interference is outstanding negative in the eastern and central, not outstanding in the western.